Program

Friday, July 4

9:00 

Welcome
S. Meairs and A. Alexander

The Clinical Challenge: Vascular Disease and Thrombolytic Treatments

9:10 

Management of Cardiovascular Disease
R. Siegel

9:30 

Treatment of Ischemic Stroke
M. Hennerici

 

 

Mechanisms of Ultrasound-mediated Thrombolysis
Chairs: M. Kaps and T.R. Porter

9:50 

Interactions between Clot and Ultrasound
C. Holland, S. Datta, J. Meunier, G. Shaw

10:10 

Cavitation and bubble dynamics
L. Crum

10:30 

Effect of Constant versus variable ultrasound
operating parameters on ultrasound-enhanced thrombolysis
A. Soltani, K.R. Volz, D.R. Hansmann

10:40 

Mechanisms of microbubble-mediated sonothrombolysis
M. Borelli, H. Williams, L. Bemock,
W. O'Brian, W. Culp

 

 

Enhancing Thrombolysis with Bubbles and New Drug Delivery Approaches
Chairs: K. Tachibana and E. Stride

11:10 

Microbubbles and Ultrasound for Thrombolysis
W. Culp

11:30 

Fibrin-targeted perfluorocarbon nanoparticles
for targeted thrombolysis
G. Lanza

11:50 

20 kHz pulsed ultrasound enhanced
thrombolysis with tPA-loaded echogenic liposomes
J. Meunier, D. Smith, Chr. Holland,
S.-L. Huang, D. McPherson, G. Shaw

12:00 

Development of an acoustically active tPA drug carrier:
experiences with a first prototype
T. Hoelscher, E. Tu, D. Ackley

12:10 

Liposome loaded microbubbles for ultrasound
targeted drug delivery
I. Lentacker, S. De Smedt, J. Demeester, N. Sanders

 

 

 

Lunch time 

 

 

13:30 

Guided Poster Walk
 for abstracts please see the abstractbook (PDF)

 

 

Safety and Bioeffects of Sonothrombolysis
Chairs: G. ter Haar and H. Furuhata

14:00 

Bioeffects in the heart
T.R. Porter

14:15 

Preclinical safety assessment of therapeutic
ultrasound
M. Nedelmann

14:30 

Simulating ultrasound thrombolysis
through the skull
J.-F. Aubry, C. Baron, M. Tanter, S. Meairs, M. Fink

14:45 

Microbubbles and ultrasound in
experimental stroke
S. Meairs

15:00 

Biological effect of a thrombotripsy
- 1-hour TCD monitoring using a diagnostic
2-4 MHz transcranial probe
D. Skoloudik, M. Bar, J. Blatný, O. Zapletal, D. ¦anák,
R. Herzig, P. Kanovský

15:10 

Decreased Hemorrhage Using Microbubble
Augmented Thrombolysis in Rabbits
W. Culp, R. Flores, J. Lowery, L. Hennings,
P. Roberson, M. Borrelli

15:20 

Efficacy and safety of transcranial sonothrombolysis
with middle frequency continuous wave in vivo
T. Saguchi, H. Onoue, M. Urashima, T. Ishibashi,
T. Abe, H. Furuhata

15:30 

Relationships of serum S100B to stroke volume
and hemorrhage score in a rabbit model of acute
ischemic stroke
R. Flores, J. Lowery, L. Hennings, B. Caldwell, W. Culp

 

 

Clinical Trials of Sonothrombolysis
Chairs: M. Hennerici, R. Siegel and W. Hacke

16:00 

Evidence for efficacy of frequencies in
diagnostic range - CLOTBUST
A. Alexandrov

16:15 

Low-frequency stroke therapy
- TRUMBI
M. Daffertshofer

16:30 

Transcranial ultrasound therapy in stroke
patients ineligible for t-PA
G. Seidel

16:45 

Microbubble-enhanced sonothrombolysis
C. Molina

17:05

Safety and Efficacy of the Sonographic Acceleration
of the Middle Cerebral Artery Recanalization:
Results of the pilot Thrombotripsy Study
D. Skoloudik, M. Bar, D. Vaclavik, O. Skoda, D. Sanak,
R. Herzig, P. Kanovsky

17:20 

Regression Analysis of Recanalization and Outcome
after Sonothrombolysis, Intravenous Thrombolysis with
Tissue Plasminogen Activator or both - Results from82 Patients
with Acute Proximal Middle Cerebral Artery Occlusion
J. Eggers

 

 

 

 

Saturday, July 5

Models and standards
Chairs: S. Meairs and C. Holland

8:30 

Ultrasound Parameters for Sonothrombolysis:
What to Measure, What to Report
M. Schafer

8:45 

System Settings, Acoustic Output, and Sonothrombolysis
J. Powers

9:00 

What is the right clot for experimental thrombolysis?
C. Dempfle

9:15 

Comparison of the Hemolytic Potential of the
Sonothrombolytic OmniWave Endovascular System
and the Possis Angiojet.  Implications for the
Development of Hemolysis Specifications
E. Lang, S. Gladstone, T. Higgins, A. Kulis, R. Balano

9:25 

120-kHz Ultrasound-Enhanced Thrombolysis in
a Porcine Intracerebral Hemorrhage Model
A. Ammi, S. Beiler, K.E. Hitchcock, S. Vaidya, K.R. Wagner,
T.D. Mast, G. deCourten-Myers, Chr.K. Holland

9:35 

Sonothrombolysis with duplex ultrasound using
a simplified in vitro model
T. Hoelscher, J. Parrish, K. Ernstrom, R. Raman,
P. Lapchak, R. Mattrey

9:45 

Computer assisted pulsatile flow-phantom for
the investigation of sonothrombolysis
F. Roessler, S. Wahba, M. Ohlrich, M. Schmieger,
P.-K. Weber, G. Seidel

 

 

 

Coffee 

 

 

Ultrasound Platforms and New Devices for Therapeutic Ultrasound
Chairs: L. Crum and J. Powers

10:15 

Dual Frequency Device for Ischemic Stroke
H. Furuhata

10:35 

Operator-Independent Device for Sonothrombolysis
A. Alexandrov, M. Schafer

10:55 

Mapping the Acoustical Transparency of the Skull
F. Vignon, B. Arnal, W. Shi, M. Burcher, J. Powers

11:05 

Sonothrombolysis with MR Guided Focused Ultrasound for the
Treatment of ICH and stroke: in vitro results
S. Harnof, G. Schiff, A. Hananel, G. Grinfeld, E. Zadicario, Z. Zibly

11:15 

An In vivo Investigation of the Use of Pulsed High Intensity
Focused Ultrasound for Thrombolysis
K. Hynynen, D. Goertz, C. Wright

11:25 

MRI navigated transcranial sonothrombolysismethod using
Brain Virtual Sonography system
H. Mitsumura, K. Inoue, M. Ogihara, J. Kubota, H. Furuhata

 

 

Invasive Treatment Strategies
Chairs: W. Culp and A. Alexandrov

11:35 

Catheter-based ultrasound thrombolysis
K. Tachibana

11:55

Experience in cardiovascular ultrasound thrombolysis
U. Rosenschein

12:15 

Combining sonothrombolysis with thrombectomy
F. Perren

12:30 

Treatment of Acute Stroke by Ultrasound Thrombectomy
M. Gounis, E. Lang, B. Hong, J. Chueh, J.C. Ford, A. Wakhloo

Round Table Discussion -
Understanding Hemorrhagic Conversion
with Sonothrombolysis: An Appraisal of Clinical Trials
Chairs: M. Hennerici and A. Alexandrov

12:40 

Discussants
M. Daffertshofer
J. Eggers
C. Molina 
F. Perren 
G. Seidel 

13:15 

Closing remarks
S. Meairs